Screening and treatment of cryptococcal meningitis...

In the News

IHI wins Grand Challenges Explorations grant

Dar es Salaam. Ifakara Health Institute (IHI) is a Grand Challenges Explorations winner, an initiative funded by the Bill & Melinda Gates Foundation.  Ms. Zawadi Mageni, a Research Scientist at …

IHI partners support Ifakara women group

Ifakara Health Institute (IHI) partners at the Innovative Vector Control Consortium (IVCC), Jed Stone and Christopher Larkin, recently distributed 300 conference bags made of cotton from the Ifakara Women’s Weavers …

Recent Projects

Understanding and enhancing approaches to quality improvement in small and medium sized private facilities in sub-Saharan Africa

This is an evaluation study that IHI is conducting in collaboration with London school of hygiene and tropical medicine. The research takes place in the context of an innovative intervention …

Vaccine Delivery Costing Study

As countries drive towards achieving high and equitable coverage of life-saving vaccines, the availability of sustainable, equitable, and predictable financing for vaccine delivery is essential. Over the last two decades, …

Screening and treatment of cryptococcal meningitis in Kilombero and Ulanga districts in Tanzania

This is a multi-site randomized trial of sertraline and high-dose Fluconazol for the treatment of cryptococcal meningitis. Patients are randomized into conventional treatment with Amphotericin B, Fluconazol and Sertraline versus Amphotericin B and Fluconazol. Ifakara did not initially start randomization but remained with an open-label design, specifically focusing on the question of added value of Sertraline to Fluconazol. In a second protocol, designed as a recruitment study for ASTRO, CRASK (Cryptococcal Antigen Screening Kilombero) screens patients from the peripheral CTCs with a easy to perform Antigen tests and refers them to Ifakara for further diagnostics and treatment within ASTRO in case of proof of cryptococcal meningitis.

This study expands access to diagnosis and treatment of cryptococcal meningitis, one of the major causes of death among people living with HIV.

Lead scientists:

Maja Weisser

Andrew Katende

Partners

Meningitis Research Foundation (MRF)
Makerere University, Kampala, Uganda
University of Minnesota, MN, USA

Funders

Meningitis Research Foundation (MRF)

Projects Location

A PIXELBASE DESIGN
© Ifakara Health Institute (IHI), 2016