Screening and treatment of cryptococcal meningitis in Kilombero and Ulanga districts in Tanzania
This is a multi-site randomized trial of sertraline and high-dose Fluconazol for the treatment of cryptococcal meningitis. Patients are randomized into conventional treatment with Amphotericin B, Fluconazol and Sertraline versus Amphotericin B and Fluconazol. Ifakara did not initially start randomization but remained with an open-label design, specifically focusing on the question of added value of Sertraline to Fluconazol. In a second protocol, designed as a recruitment study for ASTRO, CRASK (Cryptococcal Antigen Screening Kilombero) screens patients from the peripheral CTCs with a easy to perform Antigen tests and refers them to Ifakara for further diagnostics and treatment within ASTRO in case of proof of cryptococcal meningitis.
This study expands access to diagnosis and treatment of cryptococcal meningitis, one of the major causes of death among people living with HIV.