Screening and treatment of cryptococcal meningitis...

In the News

Vacancy: Research Scientist (2 posts)

IHI is looking for experienced Research Scientists to work with a project bearing the title: Broad One Health Endectocide-based Malaria Intervention in Africa (BOHEMIA) funded by the UNITAID. This project …

It’s World Malaria Day today: We’re for “Zero malaria”

We’re for “Zero malaria” (Dar es Salaam, April 25 2019) It’s World Malaria Day today. IHI joins with the Ministry of Health, Community Development, Gender, Elderly and Children through the …

Recent Projects

Calcium supplementation on pregnant women

Project summary This is a trial-based study funded by the Bill and Melinda Gates Foundation. It intends to generate evidence for decision-making on the potential non-inferiority of a lower dose …

Sustainable, Healthy, Learning Cities and Neighbourhoods

The Sustainable, Healthy, Learning Cities and Neighbourhoods is an exciting project in which IHI works with a consortium of partners from Asia and Africa to 1) develop capacity for improved …

Screening and treatment of cryptococcal meningitis in Kilombero and Ulanga districts in Tanzania

This is a multi-site randomized trial of sertraline and high-dose Fluconazol for the treatment of cryptococcal meningitis. Patients are randomized into conventional treatment with Amphotericin B, Fluconazol and Sertraline versus Amphotericin B and Fluconazol. Ifakara did not initially start randomization but remained with an open-label design, specifically focusing on the question of added value of Sertraline to Fluconazol. In a second protocol, designed as a recruitment study for ASTRO, CRASK (Cryptococcal Antigen Screening Kilombero) screens patients from the peripheral CTCs with a easy to perform Antigen tests and refers them to Ifakara for further diagnostics and treatment within ASTRO in case of proof of cryptococcal meningitis.

This study expands access to diagnosis and treatment of cryptococcal meningitis, one of the major causes of death among people living with HIV.

Lead scientists:

Maja Weisser

Andrew Katende


Meningitis Research Foundation (MRF)
Makerere University, Kampala, Uganda
University of Minnesota, MN, USA


Meningitis Research Foundation (MRF)

Projects Location

© Ifakara Health Institute (IHI), 2016