Safety and immunogenicity of direct venus...

In the News

IHI wins Grand Challenges Explorations grant

Dar es Salaam. Ifakara Health Institute (IHI) is a Grand Challenges Explorations winner, an initiative funded by the Bill & Melinda Gates Foundation.  Ms. Zawadi Mageni, a Research Scientist at …

IHI partners support Ifakara women group

Ifakara Health Institute (IHI) partners at the Innovative Vector Control Consortium (IVCC), Jed Stone and Christopher Larkin, recently distributed 300 conference bags made of cotton from the Ifakara Women’s Weavers …

Recent Projects

Understanding and enhancing approaches to quality improvement in small and medium sized private facilities in sub-Saharan Africa

This is an evaluation study that IHI is conducting in collaboration with London school of hygiene and tropical medicine. The research takes place in the context of an innovative intervention …

Vaccine Delivery Costing Study

As countries drive towards achieving high and equitable coverage of life-saving vaccines, the availability of sustainable, equitable, and predictable financing for vaccine delivery is essential. Over the last two decades, …

Clinical Trial to Evaluate the Safety and Immunogenicity in Age De-Escalation of Direct Venous Inoculation of a Plasmodium falciparum Sporozoite Vaccine in Tanzanian Adults, Children, and Infants

A single center, double blind, randomized, normal saline placebo-controlled trial of PfSPZ vaccine OR PfSPZ challenge, administered by Direct Venous Inoculation (DVI). The trial is aimed at evaluating safety, tolerability and vaccine-induced humoral and cellular immune responses of PfSPZ Vaccine in healthy male and female Tanzanian adults, adolescents, children, and infants (from 6 months old) who receive doses of 1.8×10⁶, 9.0×10⁵,  4.5×10⁵ or 2.7×10⁵ PfSPZ of PfSPZ and to assess efficacy in adults three weeks and twenty four weeks following immunization using Controlled Human Malaria Infection (CHMI). A total of 105 subjects will be enrolled at the trial completion

Lead Scientists:

Said Jongo

Salim Abdulla

Partners

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Funders

The government of Equitorial Guinea, Marathon Oil, Noble Energy and AMPCO

Projects Location

A PIXELBASE DESIGN
© Ifakara Health Institute (IHI), 2016