Evaluation of whole sporozoite vaccines for...

In the News

Project builds case for dedicated health impact assessments

A visiting scientist from an IHI implementing partner in Switzerland, Dr. Fritz Brugger, presents at the event in Dar es Salaam. PHOTO/IHI (Dar es Salaam) IHI and partners hosted a …

IHI recruits Motor Vehicle Mechanic

IHI is looking for a Motor Vehicle Mechanic to fill a vacant position in our workshop. S/he must be specialized in servicing and repairing all systems contained within automotive vehicles. …

Recent Projects

Development of a new tool for malaria mosquito surveillance to improve vector control

Malaria transmission is influenced not only by vector abundance, but as well by demographic traits such as vector species and age structure, as these influence the intensity by which the …

Demonstrating complete disruption of residual malaria transmission by eliminating Anopheles funestus mosquitoes from rural Tanzanian villages

In rural south-eastern Tanzania, where malaria prevalence has reduced by >60% since 2000, low-to-moderate transmission still persists despite very high coverage with long-lasting insecticidal bednets. Like in most residual transmission …

Evaluation of whole sporozoite vaccines for malaria elimination

This program of work is led by a clinical team at the Ifakara Health Institute Clinical Trial Facility at Kingani, Bagamoyo (IHI – CTF) which is conducting a series of studies to evaluate the potential impact of whole sporozoite malaria vaccine candidates to prevent malaria infection and thereby block transmission with the goal of achieving malaria elimination in Sub-Sahara Africa. The work is conducted in two countries; Tanzania and Equatorial Guinea. Studies and major contributions of the work to date include:

dr-omar-in-the-labBSPZC1 (NCT01540903): The first Controlled Human Malaria Infection (CHMI) study using purified fully infectious malaria sporozoites in an African country was conducted at IHI-CTF at Kingani, Bagamoyo in 2012. This trial demonstrated the safety and infectivity of the fully infectious purified sporozoites (PfSPZ Challenge) leading to the establishment of the CHMI model for testing new malaria vaccines and drugs in Africa

BSPZV1 (NCT02132299): Study conducted in IHI-CTF at Kingani, Bagamoyo between 2014-2015. This was the first PfSPZ Vaccine (radiation attenuated sporozoites) trial to be conducted in Africa. The trial established a very good safety and tolerability profile for the PfSPZ vaccine and was the basis for further studies in Mali and Equatorial Guinea.

BSPZV2 (NCT02613520): Study conducted in IHI-CTF at Kingani, Bagamoyo between 2015- 2016. Worldwide, this was the first PfSPZ Vaccine (radiation attenuated sporozoites) trial in adolescents and children. The trial established a very good safety and tolerability profile for PFSPZ vaccine in younger age groups and well as better immune responses in younger children. This work was the basis for further studies in Equatorial Guinea, Kenya and other African countries.

Partners

Swiss Tropical and Public Health Institute
Sanaria Inc.

Funders

The government of Equitorial Guinea, Marathon Oil, Noble Energy and AMPCO
Medicines for Malaria Ventures (MMV)

Projects Location

A PIXELBASE DESIGN
© Ifakara Health Institute (IHI), 2016