Malaria in Pregnancy Preventive Alternative Drugs(MiPPAD)

In the News

Scientists: Target TB interventions on these transmission hotspots

(Dar es Salaam, September 14, 2017). Scientists at Ifakara Health Institute (IHI) have recently adapted a method for identifying tuberculosis (TB) transmission hotpots using a new technique that could revolutionize …

Research Office, Lab Technicians required

IHI is looking for suitably qualified Research Officer and Laboratory Technicians to fill vacant positions in the Laboratory Unit in Bagamoyo. To apply or share, get more details about these …

Recent Projects

Understanding and enhancing approaches to quality improvement in small and medium sized private facilities in sub-Saharan Africa

This is an evaluation study that IHI is conducting in collaboration with London school of hygiene and tropical medicine. The research takes place in the context of an innovative intervention …

Vaccine Delivery Costing Study

As countries drive towards achieving high and equitable coverage of life-saving vaccines, the availability of sustainable, equitable, and predictable financing for vaccine delivery is essential. Over the last two decades, …

Malaria in Pregnancy Preventive Alternative Drugs

IPTp with SP, in a context of ITNs use, has been already proved to be cost-effective in preventing both clinical malaria in pregnant women and neonatal mortality (Sicuri et al. Unpublished). Mefloquine has the potential to be more efficacious than SP but it is also more expensive and has some tolerability and potentially compliance issues. For this reason, an economic evaluation of IPTp-MQ compared to IPTp-SP is needed.

Furthermore, little is known about the economics of malaria prevention during pregnancy in HIV infected women. To our knowledge, the only economic evaluation that considered HIV status as a factor affecting the effectiveness of IPTp was Wolfe et al (Wolfe et al. 2001). MiPPAD trials offer the opportunity to undertake a cost-effectiveness analysis based on efficacy and effectiveness of preventive interventions addressed to HIV infected and HIV non-infected pregnant women in comparison to SP. More evidence is needed about the economic burden of malaria in pregnancy in Tanzania in order to understand which actual savings, from the societal prospective, can be generated by the prevention of malaria cases through a more efficacious intervention.

Lead Scientists:

Abdulnoor Mulokozi


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European and Developing Countries Trial Partnership

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