Malaria in Pregnancy Preventive Alternative Drugs(MiPPAD)

In the News

Muhas don is new IHI board member

Prof. Kaaya. Ifakara Health Institute (IHI) Board of Governors (BOG) has appointed Prof. Sylvia Kaaya member of the IHI Board of Trustees (BOT) effective Wednesday January 10, 2018. The appointment …

Marcel steps down from IHI boards

Prof. Marcel Tanner has stepped down as Ifakara Health Institute (IHI) member of the Board of Trustees (BOT) and Board of Governors (BOG) effective Wednesday January 10, 2018. The Former …

Recent Projects

Development of a new tool for malaria mosquito surveillance to improve vector control

Malaria transmission is influenced not only by vector abundance, but as well by demographic traits such as vector species and age structure, as these influence the intensity by which the …

Demonstrating complete disruption of residual malaria transmission by eliminating Anopheles funestus mosquitoes from rural Tanzanian villages

In rural south-eastern Tanzania, where malaria prevalence has reduced by >60% since 2000, low-to-moderate transmission still persists despite very high coverage with long-lasting insecticidal bednets. Like in most residual transmission …

Malaria in Pregnancy Preventive Alternative Drugs

IPTp with SP, in a context of ITNs use, has been already proved to be cost-effective in preventing both clinical malaria in pregnant women and neonatal mortality (Sicuri et al. Unpublished). Mefloquine has the potential to be more efficacious than SP but it is also more expensive and has some tolerability and potentially compliance issues. For this reason, an economic evaluation of IPTp-MQ compared to IPTp-SP is needed.

Furthermore, little is known about the economics of malaria prevention during pregnancy in HIV infected women. To our knowledge, the only economic evaluation that considered HIV status as a factor affecting the effectiveness of IPTp was Wolfe et al (Wolfe et al. 2001). MiPPAD trials offer the opportunity to undertake a cost-effectiveness analysis based on efficacy and effectiveness of preventive interventions addressed to HIV infected and HIV non-infected pregnant women in comparison to SP. More evidence is needed about the economic burden of malaria in pregnancy in Tanzania in order to understand which actual savings, from the societal prospective, can be generated by the prevention of malaria cases through a more efficacious intervention.

Lead Scientists:

Abdulnoor Mulokozi


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European and Developing Countries Trial Partnership

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© Ifakara Health Institute (IHI), 2016