Malaria in Pregnancy Preventive Alternative Drugs(MiPPAD)

In the News

Study establishes link between gender, extramarital affairs and HIV

Dar es Salaam. A new Ifakara Health Institute study has found “a significant association between lifetime (proxy) extramarital affairs and HIV infection among women only,” with the risk being significantly …

IHI names winners of research, innovation fund

[Right-Left] Getrud, Beatrice, Theckla, and Tutu.Ifakara Health Institute (IHI) has named recipients of the 2017/18 Director’s Research and Innovation Fund. This is an internal funding mechanism aimed to support specific …

Recent Projects

Development of a new tool for malaria mosquito surveillance to improve vector control

Malaria transmission is influenced not only by vector abundance, but as well by demographic traits such as vector species and age structure, as these influence the intensity by which the …

Demonstrating complete disruption of residual malaria transmission by eliminating Anopheles funestus mosquitoes from rural Tanzanian villages

In rural south-eastern Tanzania, where malaria prevalence has reduced by >60% since 2000, low-to-moderate transmission still persists despite very high coverage with long-lasting insecticidal bednets. Like in most residual transmission …

Malaria in Pregnancy Preventive Alternative Drugs

IPTp with SP, in a context of ITNs use, has been already proved to be cost-effective in preventing both clinical malaria in pregnant women and neonatal mortality (Sicuri et al. Unpublished). Mefloquine has the potential to be more efficacious than SP but it is also more expensive and has some tolerability and potentially compliance issues. For this reason, an economic evaluation of IPTp-MQ compared to IPTp-SP is needed.

Furthermore, little is known about the economics of malaria prevention during pregnancy in HIV infected women. To our knowledge, the only economic evaluation that considered HIV status as a factor affecting the effectiveness of IPTp was Wolfe et al (Wolfe et al. 2001). MiPPAD trials offer the opportunity to undertake a cost-effectiveness analysis based on efficacy and effectiveness of preventive interventions addressed to HIV infected and HIV non-infected pregnant women in comparison to SP. More evidence is needed about the economic burden of malaria in pregnancy in Tanzania in order to understand which actual savings, from the societal prospective, can be generated by the prevention of malaria cases through a more efficacious intervention.

Lead Scientists:

Abdulnoor Mulokozi

Partners

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Funders

European and Developing Countries Trial Partnership

Projects Location

A PIXELBASE DESIGN
© Ifakara Health Institute (IHI), 2016