Mr. Tarimo is as a research scientist at IHI since July 2009. Currently, he is working toward finalizing his PhD studies in Molecular Microbiology from Nelson Mandela-African Institution of Science & Technology (NM-AIST). Brian holds a MSc in Bioinformatics from the University of Glasgow (2008) and a BSc in Molecular Biology & Biotechnology from University of Dar Es Salaam (2006). During his MSc degree, Brian’s research thesis was on the development of a mathematical model for the Glutathione (GSH) pathway in P. falciparum during its erythrocytic stages. P. falciparum uses the GSH pathway to reduce the harmful oxidative stress conditions brought about by anti-malaria drugs that are used against it such as chloroquine (CQ). A clear understanding on how the GSH pathway and its components functions provide insights and novel strategies on overcoming resistance to these anti-malarial drugs.
On joining IHI in July 2009, Brian worked as a software developer in the Data Systems unit where he was responsible for developing analytical and data-driven queries in PostgreSQL, developing of a web-based front end for data extraction, and provision of data management services to various projects across IHI. Brian’s key interest is in biomedical research and from July 2010-Ocober 2012, he was actively involved in various biomedical research activities. He provided molecular biology technical support to a study on ACT anti-malarial drug efficacy. Furthermore, he provided informatics related analysis on SNP genotyping data generated by MALDI-TOF (MassArray) from various research projects. Brian’s PhD research is focused on using high throughput proteomic analyses to understand Thioredoxin-mediated oxidative stress regulation in An. gambiae midgut epithelial cells following Plasmodium-infected blood meal ingestion. This work is fundamental to the understanding, and ultimately stopping, malaria transmission.
Currently, Brian works as a project leader in a study on Residual Malaria Transmission in Unguja island (part of Zanzibar in Tanzania). He is an enthusiastic academician and is involved in teaching and lecturing molecular biology and bioinformatics in several local universities. His current research interests are in the application of molecular biology and bioinformatics/computational biology techniques to understand human/vector host-parasite interactions during the sexual and sporogonic life stages of Plasmodium parasite, respectively, and potential interventions that can arise to control Malaria. Brian is a member of various local, regional, and international academic societies including the Tanzania Genome Network (TGN), Tanzania Society of Biochemistry and Molecular Biology (TSBMB), African Society of Bioinformatics and Computational Biology (ASBCB), International Society of Computational Biology (ISCB), and the American Society of Tropical Medicine and Hygiene (ASTMH).